Fifteen-year-old Josh has chosen to side neither with his twin sister Sophie nor with the Alchemyst, Nicholas Flamel, but rather to fight alongside Dr. John Dee and the mysterious Virginia Dare, while the immortal Machiavelli and Billy the Kid follow the Elders' plans to set loose the monsters of Alcatraz on San Francisco and trigger the end of the humani race.

With Scatty, Joan of Arc, Saint Germain, Palamedes, and Shakespeare all in Danu Talis, Sophie is on her own with the ever-weakening Nicholas and Perenelle Flamel. She must depend on Niten to help her find an immortal to teach her Earth Magic. The surprise is that she will find her teacher in the most ordinary of places.