Jamie Grimm is a middle schooler on a mission: he wants to become the world's greatest standup comedian, even if he doesn't have a lot to laugh about these days. He's new in town and stuck living with his aunt, uncle, and their evil son Stevie, a bully who doesn't let Jamie's wheelchair stop him from giving Jamie a good pounding every once in awhile.

When people look at George, they think they see a boy. But she knows she's not a boy. She knows she's a girl. George thinks she'll have to keep this a secret forever. Then her teacher announces that their fourth-grade class play is going to be Charlotte's Web. George really, really, REALLY wants to play Charlotte. But the teacher says she can't even try out for the part...because she's a boy. With the help of her best friend, Kelly, George comes up...